Silverback Therapeutics to Present SBT6290 Preclinical Data at the AACR 2021 Annual Conference
SBT6290 Shown to Activate Myeloid Cells and Drive Anti-tumor Effects in Nectin4-expressing Solid Tumors
“SBT6290 showcases the versatility of our ImmunoTAC platform and along with our lead program SBT6050, exemplifies our goal to target difficult-to-treat solid tumors subset by subset. We are building on learnings from SBT6050, leveraging the same TLR8 linker-payload, which is highly transferrable across different targeting antibodies,” said
SBT6290 comprises a selective TLR8 agonist conjugated to a Nectin4-specific monoclonal antibody. Nectin4 is a cell surface adhesion molecule that is overexpressed in multiple solid tumor types including urothelial, triple negative breast, squamous cell head and neck, and non-small cell lung cancers, with limited expression in normal tissues.
The abstract is now available on the AACR Annual Meeting website. Details of the poster presentation are as follows:
Title: SBT6290, a Systemically Administered Nectin4-Directed TLR8 ImmunoTAC® Product Candidate, is Designed for Tumor-localized Activation of Myeloid Cells
Abstract Number: 1858
Session Category: Immunology
Session Title: Therapeutic Antibodies, Including Engineered Antibodies
Virtual Poster Session Date and Time: The poster will be made available on the AACR website and Silverback website on
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